orf: report of eleven cases in five iranian families

background parapox virus is the causative agent of orf disease which is basically seen in sheep and goats. it can betransferred to the human by direct contact with infected animals or indirect contact to infected meat or contaminated butchery instruments like knife. the skin lesions are usually found in fingers. patients totally, 11 subjects from five families infected with orf disease were surveyed. the diagnosis was verified on clinical manifestations and pathological changes. local antiseptic (betadin) and tetracycline ointment were administered for all patients, however, 3 cases were treated with oral antibiotic. no disseminated signs or complications have been reported and patients cured in the third (6 cases) or forth week (5 cases). little scars were noted in 3 cases after one month follow up. conclusion if there is a similar lesion in the members of a family, one should notice the background of epidemiological and clinical manifestations. despite the rarity of orf disease, its spread still exists in urban families, therefore, it is essential to wear gloves at the time of touching meat to prevent infection.